Mutations in Kelch-like 3 and Cullin 3 cause hypertension and electrolyte abnormalities
Identifieur interne : 005308 ( Main/Exploration ); précédent : 005307; suivant : 005309Mutations in Kelch-like 3 and Cullin 3 cause hypertension and electrolyte abnormalities
Auteurs : Lynn M. Boyden [États-Unis] ; Murim Choi [États-Unis] ; Keith A. Choate [États-Unis] ; Carol J. Nelson-Williams [États-Unis] ; Anita Farhi [États-Unis] ; Hakan R. Toka [États-Unis] ; Irina R. Tikhonova [États-Unis] ; Robert Bjornson [États-Unis] ; Shrikant M. Mane [États-Unis] ; Giacomo Colussi [Italie] ; Marcel Lebel [Canada] ; Richard D. Gordon [Australie] ; Ben A. Semmekrot [Pays-Bas] ; Alain Poujol [France] ; Matti J. V Lim Ki [Finlande] ; Maria E. De Ferrari [Italie] ; Sami A. Sanjad [Liban] ; Michael Gutkin [États-Unis] ; Fiona E. Karet [Royaume-Uni] ; Joseph R. Tucci [États-Unis] ; Jim R. Stockigt [Australie] ; Kim M. Keppler-Noreuil [États-Unis] ; Craig C. Porter [États-Unis] ; Sudhir K. Anand [États-Unis] ; Margo L. Whiteford [Royaume-Uni] ; Ira D. Davis [États-Unis] ; Stephanie B. Dewar [États-Unis] ; Alberto Bettinelli [Italie] ; Jeffrey J. Fadrowski [États-Unis] ; Craig W. Belsha [États-Unis] ; Tracy E. Hunley [États-Unis] ; Raoul D. Nelson [États-Unis] ; Howard Trachtman [États-Unis] ; Trevor R. P. Cole [Royaume-Uni] ; Maury Pinsk [Canada] ; Detlef Bockenhauer [Royaume-Uni] ; Mohan Shenoy [Royaume-Uni] ; Priya Vaidyanathan [États-Unis] ; John W. Foreman [États-Unis] ; Majid Rasoulpour [États-Unis] ; Farook Thameem [États-Unis] ; Hania Z. Al-Shahrouri [États-Unis] ; Jai Radhakrishnan [États-Unis] ; Ali G. Gharavi [États-Unis] ; Beatrice Goilav [États-Unis] ; Richard P. Lifton [États-Unis]Source :
- Nature [ 0028-0836 ] ; 2012.
Abstract
Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease. A rare Mendelian syndrome, pseudohypoaldosteronism type II (PHAII), featuring hypertension, hyperkalemia, and metabolic acidosis, has revealed previously unrecognized physiology orchestrating the balance between renal salt reabsorption versus K+ and H+ excretion
Url:
DOI: 10.1038/nature10814
PubMed: 22266938
PubMed Central: 3278668
Affiliations:
- Australie, Canada, Finlande, France, Italie, Liban, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Californie, Caroline du Nord, Connecticut, District de Columbia, Grand Londres, Grand Manchester, Gueldre, Illinois, Iowa, Lombardie, Maryland, Massachusetts, Midlands de l'Ouest, Missouri (État), New Jersey, Pennsylvanie, Provence-Alpes-Côte d'Azur, Rhode Island, Tennessee, Texas, Utah, Victoria (État), Wisconsin, État de New York
- Aix-en-Provence, Birmingham, Cambridge, Londres, Manchester, Melbourne, Milan, Nimègue
- Université de Cambridge
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002D60
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- to stream Pmc, to step Checkpoint: 001E39
- to stream Ncbi, to step Merge: 000C91
- to stream Ncbi, to step Curation: 000C91
- to stream Ncbi, to step Checkpoint: 000C91
- to stream Main, to step Merge: 005526
- to stream Main, to step Curation: 005308
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mutations in <italic>Kelch-like 3</italic>
and <italic>Cullin 3</italic>
cause hypertension and electrolyte abnormalities</title>
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<wicri:regionArea>Department of Pediatrics, Canisius Wilhelmina Hospital, Nijmegen</wicri:regionArea>
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<author><name sortKey="V Lim Ki, Matti J" sort="V Lim Ki, Matti J" uniqKey="V Lim Ki M" first="Matti J." last="V Lim Ki">Matti J. V Lim Ki</name>
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<author><name sortKey="De Ferrari, Maria E" sort="De Ferrari, Maria E" uniqKey="De Ferrari M" first="Maria E." last="De Ferrari">Maria E. De Ferrari</name>
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<author><name sortKey="Sanjad, Sami A" sort="Sanjad, Sami A" uniqKey="Sanjad S" first="Sami A." last="Sanjad">Sami A. Sanjad</name>
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<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, American University Medical Center, Beirut</wicri:regionArea>
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<author><name sortKey="Gutkin, Michael" sort="Gutkin, Michael" uniqKey="Gutkin M" first="Michael" last="Gutkin">Michael Gutkin</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne</wicri:regionArea>
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<author><name sortKey="Keppler Noreuil, Kim M" sort="Keppler Noreuil, Kim M" uniqKey="Keppler Noreuil K" first="Kim M." last="Keppler-Noreuil">Kim M. Keppler-Noreuil</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Medical Genetics, Department of Pediatrics, University of Iowa Children’s Hospital, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Medical Genetics, Department of Pediatrics, University of Iowa Children’s Hospital, Iowa City, Iowa</wicri:regionArea>
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<author><name sortKey="Porter, Craig C" sort="Porter, Craig C" uniqKey="Porter C" first="Craig C." last="Porter">Craig C. Porter</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin</wicri:regionArea>
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<author><name sortKey="Anand, Sudhir K" sort="Anand, Sudhir K" uniqKey="Anand S" first="Sudhir K." last="Anand">Sudhir K. Anand</name>
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<wicri:regionArea>Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California</wicri:regionArea>
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<author><name sortKey="Whiteford, Margo L" sort="Whiteford, Margo L" uniqKey="Whiteford M" first="Margo L." last="Whiteford">Margo L. Whiteford</name>
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<author><name sortKey="Davis, Ira D" sort="Davis, Ira D" uniqKey="Davis I" first="Ira D." last="Davis">Ira D. Davis</name>
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<author><name sortKey="Dewar, Stephanie B" sort="Dewar, Stephanie B" uniqKey="Dewar S" first="Stephanie B." last="Dewar">Stephanie B. Dewar</name>
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<author><name sortKey="Bettinelli, Alberto" sort="Bettinelli, Alberto" uniqKey="Bettinelli A" first="Alberto" last="Bettinelli">Alberto Bettinelli</name>
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<author><name sortKey="Fadrowski, Jeffrey J" sort="Fadrowski, Jeffrey J" uniqKey="Fadrowski J" first="Jeffrey J." last="Fadrowski">Jeffrey J. Fadrowski</name>
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<wicri:regionArea>Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland</wicri:regionArea>
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<author><name sortKey="Belsha, Craig W" sort="Belsha, Craig W" uniqKey="Belsha C" first="Craig W." last="Belsha">Craig W. Belsha</name>
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<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Saint Louis University Health Sciences Center, St. Louis, Missouri</wicri:regionArea>
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<author><name sortKey="Hunley, Tracy E" sort="Hunley, Tracy E" uniqKey="Hunley T" first="Tracy E." last="Hunley">Tracy E. Hunley</name>
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<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea>
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<author><name sortKey="Nelson, Raoul D" sort="Nelson, Raoul D" uniqKey="Nelson R" first="Raoul D." last="Nelson">Raoul D. Nelson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, Utah</wicri:regionArea>
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<author><name sortKey="Trachtman, Howard" sort="Trachtman, Howard" uniqKey="Trachtman H" first="Howard" last="Trachtman">Howard Trachtman</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Nephrology, Cohen Children’s Medical Center of New York, New Hyde Park, New York, USA</nlm:aff>
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<author><name sortKey="Cole, Trevor R P" sort="Cole, Trevor R P" uniqKey="Cole T" first="Trevor R. P." last="Cole">Trevor R. P. Cole</name>
<affiliation wicri:level="3"><nlm:aff id="A28">West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, United Kingdom</nlm:aff>
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<author><name sortKey="Pinsk, Maury" sort="Pinsk, Maury" uniqKey="Pinsk M" first="Maury" last="Pinsk">Maury Pinsk</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Division of Nephrology, Department of Pediatrics, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
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<author><name sortKey="Bockenhauer, Detlef" sort="Bockenhauer, Detlef" uniqKey="Bockenhauer D" first="Detlef" last="Bockenhauer">Detlef Bockenhauer</name>
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<author><name sortKey="Shenoy, Mohan" sort="Shenoy, Mohan" uniqKey="Shenoy M" first="Mohan" last="Shenoy">Mohan Shenoy</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Department of Nephrology, Royal Manchester Children’s Hospital, Manchester, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Nephrology, Royal Manchester Children’s Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaidyanathan, Priya" sort="Vaidyanathan, Priya" uniqKey="Vaidyanathan P" first="Priya" last="Vaidyanathan">Priya Vaidyanathan</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Department of Endocrinology, Children’s National Medical Center, Washington, DC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Endocrinology, Children’s National Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foreman, John W" sort="Foreman, John W" uniqKey="Foreman J" first="John W." last="Foreman">John W. Foreman</name>
<affiliation wicri:level="2"><nlm:aff id="A33">Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasoulpour, Majid" sort="Rasoulpour, Majid" uniqKey="Rasoulpour M" first="Majid" last="Rasoulpour">Majid Rasoulpour</name>
<affiliation wicri:level="2"><nlm:aff id="A34">Division of Nephrology, Connecticut Children’s Medical Center, Hartford, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Connecticut Children’s Medical Center, Hartford, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thameem, Farook" sort="Thameem, Farook" uniqKey="Thameem F" first="Farook" last="Thameem">Farook Thameem</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Al Shahrouri, Hania Z" sort="Al Shahrouri, Hania Z" uniqKey="Al Shahrouri H" first="Hania Z." last="Al-Shahrouri">Hania Z. Al-Shahrouri</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radhakrishnan, Jai" sort="Radhakrishnan, Jai" uniqKey="Radhakrishnan J" first="Jai" last="Radhakrishnan">Jai Radhakrishnan</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gharavi, Ali G" sort="Gharavi, Ali G" uniqKey="Gharavi A" first="Ali G." last="Gharavi">Ali G. Gharavi</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goilav, Beatrice" sort="Goilav, Beatrice" uniqKey="Goilav B" first="Beatrice" last="Goilav">Beatrice Goilav</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Division of Nephrology, Children’s Hospital at Montefiore, Bronx, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Children’s Hospital at Montefiore, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lifton, Richard P" sort="Lifton, Richard P" uniqKey="Lifton R" first="Richard P." last="Lifton">Richard P. Lifton</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mutations in <italic>Kelch-like 3</italic>
and <italic>Cullin 3</italic>
cause hypertension and electrolyte abnormalities</title>
<author><name sortKey="Boyden, Lynn M" sort="Boyden, Lynn M" uniqKey="Boyden L" first="Lynn M." last="Boyden">Lynn M. Boyden</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Murim" sort="Choi, Murim" uniqKey="Choi M" first="Murim" last="Choi">Murim Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choate, Keith A" sort="Choate, Keith A" uniqKey="Choate K" first="Keith A." last="Choate">Keith A. Choate</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nelson Williams, Carol J" sort="Nelson Williams, Carol J" uniqKey="Nelson Williams C" first="Carol J." last="Nelson-Williams">Carol J. Nelson-Williams</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Farhi, Anita" sort="Farhi, Anita" uniqKey="Farhi A" first="Anita" last="Farhi">Anita Farhi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toka, Hakan R" sort="Toka, Hakan R" uniqKey="Toka H" first="Hakan R." last="Toka">Hakan R. Toka</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tikhonova, Irina R" sort="Tikhonova, Irina R" uniqKey="Tikhonova I" first="Irina R." last="Tikhonova">Irina R. Tikhonova</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Yale Center for Genome Analysis, Yale University, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Yale Center for Genome Analysis, Yale University, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bjornson, Robert" sort="Bjornson, Robert" uniqKey="Bjornson R" first="Robert" last="Bjornson">Robert Bjornson</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Yale Center for Genome Analysis, Yale University, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Yale Center for Genome Analysis, Yale University, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mane, Shrikant M" sort="Mane, Shrikant M" uniqKey="Mane S" first="Shrikant M." last="Mane">Shrikant M. Mane</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Yale Center for Genome Analysis, Yale University, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Yale Center for Genome Analysis, Yale University, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colussi, Giacomo" sort="Colussi, Giacomo" uniqKey="Colussi G" first="Giacomo" last="Colussi">Giacomo Colussi</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Nephrology Unit, Niguarda-Ca’ Granda Hospital, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Nephrology Unit, Niguarda-Ca’ Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lebel, Marcel" sort="Lebel, Marcel" uniqKey="Lebel M" first="Marcel" last="Lebel">Marcel Lebel</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Medicine, Laval University, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Laval University, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gordon, Richard D" sort="Gordon, Richard D" uniqKey="Gordon R" first="Richard D." last="Gordon">Richard D. Gordon</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Endocrine Hypertension Research Centre, University of Queensland School of Medicine, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Endocrine Hypertension Research Centre, University of Queensland School of Medicine, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Semmekrot, Ben A" sort="Semmekrot, Ben A" uniqKey="Semmekrot B" first="Ben A." last="Semmekrot">Ben A. Semmekrot</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Department of Pediatrics, Canisius Wilhelmina Hospital, Nijmegen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatrics, Canisius Wilhelmina Hospital, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poujol, Alain" sort="Poujol, Alain" uniqKey="Poujol A" first="Alain" last="Poujol">Alain Poujol</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Pediatrics, Pays d’Aix Hospital, Aix-en-Provence, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pediatrics, Pays d’Aix Hospital, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="V Lim Ki, Matti J" sort="V Lim Ki, Matti J" uniqKey="V Lim Ki M" first="Matti J." last="V Lim Ki">Matti J. V Lim Ki</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Ferrari, Maria E" sort="De Ferrari, Maria E" uniqKey="De Ferrari M" first="Maria E." last="De Ferrari">Maria E. De Ferrari</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Nephrology Unit, Niguarda-Ca’ Granda Hospital, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Nephrology Unit, Niguarda-Ca’ Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanjad, Sami A" sort="Sanjad, Sami A" uniqKey="Sanjad S" first="Sami A." last="Sanjad">Sami A. Sanjad</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Department of Pediatrics and Adolescent Medicine, American University Medical Center, Beirut, Lebanon</nlm:aff>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, American University Medical Center, Beirut</wicri:regionArea>
<wicri:noRegion>Beirut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gutkin, Michael" sort="Gutkin, Michael" uniqKey="Gutkin M" first="Michael" last="Gutkin">Michael Gutkin</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Hypertension Research Center, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hypertension Research Center, University of Medicine and Dentistry of New Jersey, Newark, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karet, Fiona E" sort="Karet, Fiona E" uniqKey="Karet F" first="Fiona E." last="Karet">Fiona E. Karet</name>
<affiliation wicri:level="4"><nlm:aff id="A13">Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medical Genetics, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tucci, Joseph R" sort="Tucci, Joseph R" uniqKey="Tucci J" first="Joseph R." last="Tucci">Joseph R. Tucci</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Division of Endocrinology, Roger Williams Medical Center, Providence, Rhode Island, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Roger Williams Medical Center, Providence, Rhode Island</wicri:regionArea>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stockigt, Jim R" sort="Stockigt, Jim R" uniqKey="Stockigt J" first="Jim R." last="Stockigt">Jim R. Stockigt</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Endocrinology and Diabetes, Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keppler Noreuil, Kim M" sort="Keppler Noreuil, Kim M" uniqKey="Keppler Noreuil K" first="Kim M." last="Keppler-Noreuil">Kim M. Keppler-Noreuil</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Medical Genetics, Department of Pediatrics, University of Iowa Children’s Hospital, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Medical Genetics, Department of Pediatrics, University of Iowa Children’s Hospital, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Porter, Craig C" sort="Porter, Craig C" uniqKey="Porter C" first="Craig C." last="Porter">Craig C. Porter</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Division of Nephrology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anand, Sudhir K" sort="Anand, Sudhir K" uniqKey="Anand S" first="Sudhir K." last="Anand">Sudhir K. Anand</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Whiteford, Margo L" sort="Whiteford, Margo L" uniqKey="Whiteford M" first="Margo L." last="Whiteford">Margo L. Whiteford</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Duncan Guthrie Institute of Medical Genetics, Royal Hospital for Sick Children, Glasgow, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Duncan Guthrie Institute of Medical Genetics, Royal Hospital for Sick Children, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davis, Ira D" sort="Davis, Ira D" uniqKey="Davis I" first="Ira D." last="Davis">Ira D. Davis</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Baxter Healthcare Corporation, McGaw Park, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baxter Healthcare Corporation, McGaw Park, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dewar, Stephanie B" sort="Dewar, Stephanie B" uniqKey="Dewar S" first="Stephanie B." last="Dewar">Stephanie B. Dewar</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bettinelli, Alberto" sort="Bettinelli, Alberto" uniqKey="Bettinelli A" first="Alberto" last="Bettinelli">Alberto Bettinelli</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Division of Pediatrics, Mandic Hospital, Merate, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Pediatrics, Mandic Hospital, Merate</wicri:regionArea>
<wicri:noRegion>Merate</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fadrowski, Jeffrey J" sort="Fadrowski, Jeffrey J" uniqKey="Fadrowski J" first="Jeffrey J." last="Fadrowski">Jeffrey J. Fadrowski</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belsha, Craig W" sort="Belsha, Craig W" uniqKey="Belsha C" first="Craig W." last="Belsha">Craig W. Belsha</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Division of Nephrology, Department of Pediatrics, Saint Louis University Health Sciences Center, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Saint Louis University Health Sciences Center, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunley, Tracy E" sort="Hunley, Tracy E" uniqKey="Hunley T" first="Tracy E." last="Hunley">Tracy E. Hunley</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Division of Nephrology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nelson, Raoul D" sort="Nelson, Raoul D" uniqKey="Nelson R" first="Raoul D." last="Nelson">Raoul D. Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Division of Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trachtman, Howard" sort="Trachtman, Howard" uniqKey="Trachtman H" first="Howard" last="Trachtman">Howard Trachtman</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Nephrology, Cohen Children’s Medical Center of New York, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Cohen Children’s Medical Center of New York, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cole, Trevor R P" sort="Cole, Trevor R P" uniqKey="Cole T" first="Trevor R. P." last="Cole">Trevor R. P. Cole</name>
<affiliation wicri:level="3"><nlm:aff id="A28">West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinsk, Maury" sort="Pinsk, Maury" uniqKey="Pinsk M" first="Maury" last="Pinsk">Maury Pinsk</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Division of Nephrology, Department of Pediatrics, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Nephrology, Department of Pediatrics, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bockenhauer, Detlef" sort="Bockenhauer, Detlef" uniqKey="Bockenhauer D" first="Detlef" last="Bockenhauer">Detlef Bockenhauer</name>
<affiliation wicri:level="3"><nlm:aff id="A30">Renal Unit, University College London Institute of Child Health, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Renal Unit, University College London Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shenoy, Mohan" sort="Shenoy, Mohan" uniqKey="Shenoy M" first="Mohan" last="Shenoy">Mohan Shenoy</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Department of Nephrology, Royal Manchester Children’s Hospital, Manchester, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Nephrology, Royal Manchester Children’s Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaidyanathan, Priya" sort="Vaidyanathan, Priya" uniqKey="Vaidyanathan P" first="Priya" last="Vaidyanathan">Priya Vaidyanathan</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Department of Endocrinology, Children’s National Medical Center, Washington, DC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Endocrinology, Children’s National Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foreman, John W" sort="Foreman, John W" uniqKey="Foreman J" first="John W." last="Foreman">John W. Foreman</name>
<affiliation wicri:level="2"><nlm:aff id="A33">Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasoulpour, Majid" sort="Rasoulpour, Majid" uniqKey="Rasoulpour M" first="Majid" last="Rasoulpour">Majid Rasoulpour</name>
<affiliation wicri:level="2"><nlm:aff id="A34">Division of Nephrology, Connecticut Children’s Medical Center, Hartford, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Connecticut Children’s Medical Center, Hartford, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thameem, Farook" sort="Thameem, Farook" uniqKey="Thameem F" first="Farook" last="Thameem">Farook Thameem</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Al Shahrouri, Hania Z" sort="Al Shahrouri, Hania Z" uniqKey="Al Shahrouri H" first="Hania Z." last="Al-Shahrouri">Hania Z. Al-Shahrouri</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radhakrishnan, Jai" sort="Radhakrishnan, Jai" uniqKey="Radhakrishnan J" first="Jai" last="Radhakrishnan">Jai Radhakrishnan</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gharavi, Ali G" sort="Gharavi, Ali G" uniqKey="Gharavi A" first="Ali G." last="Gharavi">Ali G. Gharavi</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goilav, Beatrice" sort="Goilav, Beatrice" uniqKey="Goilav B" first="Beatrice" last="Goilav">Beatrice Goilav</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Division of Nephrology, Children’s Hospital at Montefiore, Bronx, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Children’s Hospital at Montefiore, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lifton, Richard P" sort="Lifton, Richard P" uniqKey="Lifton R" first="Richard P." last="Lifton">Richard P. Lifton</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature</title>
<idno type="ISSN">0028-0836</idno>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease. A rare Mendelian syndrome, pseudohypoaldosteronism type II (PHAII), featuring hypertension, hyperkalemia, and metabolic acidosis, has revealed previously unrecognized physiology orchestrating the balance between renal salt reabsorption versus K<sup>+</sup>
and H<sup>+</sup>
excretion<sup><xref rid="R1" ref-type="bibr">1</xref>
</sup>
. We used exome sequencing to identify mutations in <italic>Kelch-like 3</italic>
(<italic>KLHL3</italic>
) or <italic>Cullin 3</italic>
(<italic>CUL3</italic>
) in 41 PHAII kindreds. <italic>KLHL3</italic>
mutations are either recessive or dominant, while <italic>CUL3</italic>
mutations are dominant and predominantly <italic>de novo</italic>
. CUL3 and BTB-Kelch proteins such as KLHL3 are components of Cullin/RING E3 ligase complexes (CRLs) that ubiquitinate substrates bound to Kelch propeller domains<sup><xref rid="R2" ref-type="bibr">2</xref>
–<xref rid="R8" ref-type="bibr">8</xref>
</sup>
. Dominant <italic>KLHL3</italic>
mutations are clustered in short segments within the Kelch propeller and BTB domains implicated in substrate<sup><xref rid="R9" ref-type="bibr">9</xref>
</sup>
and Cullin<sup><xref rid="R5" ref-type="bibr">5</xref>
</sup>
binding, respectively. Diverse <italic>CUL3</italic>
mutations all result in skipping of exon 9, producing an in-frame deletion. Because dominant <italic>KLHL3</italic>
and <italic>CUL3</italic>
mutations both phenocopy recessive loss-of-function <italic>KLHL3</italic>
mutations, they may abrogate ubiquitination of KLHL3 substrates. Disease features are reversed by thiazide diuretics, which inhibit the Na-Cl cotransporter (NCC) in the distal nephron of the kidney; KLHL3 and CUL3 are expressed in this location, suggesting a mechanistic link between <italic>KLHL3</italic>
/<italic>CUL3</italic>
mutations, increased Na-Cl reabsorption, and disease pathogenesis. These findings demonstrate the utility of exome sequencing in disease gene identification despite combined complexities of locus heterogeneity, mixed models of transmission, and frequent <italic>de novo</italic>
mutation, and establish a fundamental role for KLHL3/CUL3 in blood pressure, K<sup>+</sup>
, and pH homeostasis.</p>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Liban</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Connecticut</li>
<li>District de Columbia</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Gueldre</li>
<li>Illinois</li>
<li>Iowa</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Midlands de l'Ouest</li>
<li>Missouri (État)</li>
<li>New Jersey</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhode Island</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Utah</li>
<li>Victoria (État)</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Aix-en-Provence</li>
<li>Birmingham</li>
<li>Cambridge</li>
<li>Londres</li>
<li>Manchester</li>
<li>Melbourne</li>
<li>Milan</li>
<li>Nimègue</li>
</settlement>
<orgName><li>Université de Cambridge</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Boyden, Lynn M" sort="Boyden, Lynn M" uniqKey="Boyden L" first="Lynn M." last="Boyden">Lynn M. Boyden</name>
</region>
<name sortKey="Al Shahrouri, Hania Z" sort="Al Shahrouri, Hania Z" uniqKey="Al Shahrouri H" first="Hania Z." last="Al-Shahrouri">Hania Z. Al-Shahrouri</name>
<name sortKey="Anand, Sudhir K" sort="Anand, Sudhir K" uniqKey="Anand S" first="Sudhir K." last="Anand">Sudhir K. Anand</name>
<name sortKey="Belsha, Craig W" sort="Belsha, Craig W" uniqKey="Belsha C" first="Craig W." last="Belsha">Craig W. Belsha</name>
<name sortKey="Bjornson, Robert" sort="Bjornson, Robert" uniqKey="Bjornson R" first="Robert" last="Bjornson">Robert Bjornson</name>
<name sortKey="Choate, Keith A" sort="Choate, Keith A" uniqKey="Choate K" first="Keith A." last="Choate">Keith A. Choate</name>
<name sortKey="Choi, Murim" sort="Choi, Murim" uniqKey="Choi M" first="Murim" last="Choi">Murim Choi</name>
<name sortKey="Davis, Ira D" sort="Davis, Ira D" uniqKey="Davis I" first="Ira D." last="Davis">Ira D. Davis</name>
<name sortKey="Dewar, Stephanie B" sort="Dewar, Stephanie B" uniqKey="Dewar S" first="Stephanie B." last="Dewar">Stephanie B. Dewar</name>
<name sortKey="Fadrowski, Jeffrey J" sort="Fadrowski, Jeffrey J" uniqKey="Fadrowski J" first="Jeffrey J." last="Fadrowski">Jeffrey J. Fadrowski</name>
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<name sortKey="Foreman, John W" sort="Foreman, John W" uniqKey="Foreman J" first="John W." last="Foreman">John W. Foreman</name>
<name sortKey="Gharavi, Ali G" sort="Gharavi, Ali G" uniqKey="Gharavi A" first="Ali G." last="Gharavi">Ali G. Gharavi</name>
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<name sortKey="Keppler Noreuil, Kim M" sort="Keppler Noreuil, Kim M" uniqKey="Keppler Noreuil K" first="Kim M." last="Keppler-Noreuil">Kim M. Keppler-Noreuil</name>
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<name sortKey="Tikhonova, Irina R" sort="Tikhonova, Irina R" uniqKey="Tikhonova I" first="Irina R." last="Tikhonova">Irina R. Tikhonova</name>
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<name sortKey="Trachtman, Howard" sort="Trachtman, Howard" uniqKey="Trachtman H" first="Howard" last="Trachtman">Howard Trachtman</name>
<name sortKey="Tucci, Joseph R" sort="Tucci, Joseph R" uniqKey="Tucci J" first="Joseph R." last="Tucci">Joseph R. Tucci</name>
<name sortKey="Vaidyanathan, Priya" sort="Vaidyanathan, Priya" uniqKey="Vaidyanathan P" first="Priya" last="Vaidyanathan">Priya Vaidyanathan</name>
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<country name="Italie"><region name="Lombardie"><name sortKey="Colussi, Giacomo" sort="Colussi, Giacomo" uniqKey="Colussi G" first="Giacomo" last="Colussi">Giacomo Colussi</name>
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<country name="Canada"><noRegion><name sortKey="Lebel, Marcel" sort="Lebel, Marcel" uniqKey="Lebel M" first="Marcel" last="Lebel">Marcel Lebel</name>
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<country name="Liban"><noRegion><name sortKey="Sanjad, Sami A" sort="Sanjad, Sami A" uniqKey="Sanjad S" first="Sami A." last="Sanjad">Sami A. Sanjad</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Karet, Fiona E" sort="Karet, Fiona E" uniqKey="Karet F" first="Fiona E." last="Karet">Fiona E. Karet</name>
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<name sortKey="Bockenhauer, Detlef" sort="Bockenhauer, Detlef" uniqKey="Bockenhauer D" first="Detlef" last="Bockenhauer">Detlef Bockenhauer</name>
<name sortKey="Cole, Trevor R P" sort="Cole, Trevor R P" uniqKey="Cole T" first="Trevor R. P." last="Cole">Trevor R. P. Cole</name>
<name sortKey="Shenoy, Mohan" sort="Shenoy, Mohan" uniqKey="Shenoy M" first="Mohan" last="Shenoy">Mohan Shenoy</name>
<name sortKey="Whiteford, Margo L" sort="Whiteford, Margo L" uniqKey="Whiteford M" first="Margo L." last="Whiteford">Margo L. Whiteford</name>
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</record>
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